Pub. Date : 1992 Feb 15
PMID : 1311561
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Investigation of guanine-nucleotide-binding protein involvement and regulation of cyclic AMP metabolism in interleukin 1 signal transduction. | Guanine Nucleotides | interleukin 1 complex | Mus musculus |
| 2 | Investigation of guanine-nucleotide-binding protein involvement and regulation of cyclic AMP metabolism in interleukin 1 signal transduction. | Cyclic AMP | interleukin 1 complex | Mus musculus |
| 3 | The involvement of guanine-nucleotide-binding proteins (G-proteins) and regulation of cyclic AMP (cAMP) in interleukin 1 (IL1) signal transduction has been investigated in EL4 and 7OZ/3 cells expressing Type 1 and Type 2 IL1 receptors respectively. | Cyclic AMP | interleukin 1 complex | Mus musculus |
| 4 | In EL4-cell membrane preparations the kinetics of 125I-IL1 binding were altered in the presence of guanosine 5"-[beta gamma-imido]triphosphate, resulting in the formation of a higher-affinity state for IL1 binding. | Guanylyl Imidodiphosphate | interleukin 1 complex | Mus musculus |
| 5 | In EL4-cell membrane preparations the kinetics of 125I-IL1 binding were altered in the presence of guanosine 5"-[beta gamma-imido]triphosphate, resulting in the formation of a higher-affinity state for IL1 binding. | Guanylyl Imidodiphosphate | interleukin 1 complex | Mus musculus |
| 6 | These results suggest that IL1 receptor function may be regulated by guanine nucleotides; however, the mechanism appears to differ from that exhibited by conventional G-protein-linked receptors. | Guanine Nucleotides | interleukin 1 complex | Mus musculus |