Pub. Date : 2003 Sep 15
PMID : 12970194
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A genetic screen to isolate Saccharomyces cerevisiae strains bearing mutations in genes required for the conversion of IRP1 to c-aconitase led to the identification of a previously uncharacterized, essential gene, which we call CFD1 (cytosolic Fe-S cluster deficient). | Iron | iron-sulfur cluster assembly protein CFD1 | Saccharomyces cerevisiae S288C |
| 2 | A non-lethal mutation of CFD1 (cfd1-1) reduced c-aconitase specific activity in IRP1-transformed yeast by >90%, although IRP1 in these cells could be readily converted to c-aconitase in vitro upon incubation with iron alone. | Iron | iron-sulfur cluster assembly protein CFD1 | Saccharomyces cerevisiae S288C |
| 3 | A non-lethal mutation of CFD1 (cfd1-1) reduced c-aconitase specific activity in IRP1-transformed yeast by >90%, although IRP1 in these cells could be readily converted to c-aconitase in vitro upon incubation with iron alone. | Iron | iron-sulfur cluster assembly protein CFD1 | Saccharomyces cerevisiae S288C |