PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12970194-2 2003 A genetic screen to isolate Saccharomyces cerevisiae strains bearing mutations in genes required for the conversion of IRP1 to c-aconitase led to the identification of a previously uncharacterized, essential gene, which we call CFD1 (cytosolic Fe-S cluster deficient). Iron 244-248 iron-sulfur cluster assembly protein CFD1 Saccharomyces cerevisiae S288C 228-232 12970194-4 2003 A non-lethal mutation of CFD1 (cfd1-1) reduced c-aconitase specific activity in IRP1-transformed yeast by >90%, although IRP1 in these cells could be readily converted to c-aconitase in vitro upon incubation with iron alone. Iron 216-220 iron-sulfur cluster assembly protein CFD1 Saccharomyces cerevisiae S288C 25-29 12970194-4 2003 A non-lethal mutation of CFD1 (cfd1-1) reduced c-aconitase specific activity in IRP1-transformed yeast by >90%, although IRP1 in these cells could be readily converted to c-aconitase in vitro upon incubation with iron alone. Iron 216-220 iron-sulfur cluster assembly protein CFD1 Saccharomyces cerevisiae S288C 31-37