Title : Protein-tyrosine phosphatase 1B as new activator for hepatic lipogenesis via sterol regulatory element-binding protein-1 gene expression.

Pub. Date : 2003 Oct 31

PMID : 12941932






3 Functional Relationships(s)
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1 We found that insulin-resistant rats fed a diet high in fructose showed an increased proteintyrosine phosphatase 1B (PTP1B) content with strong expression of SREBP-1 mRNA in the liver. Fructose protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus
2 We found that insulin-resistant rats fed a diet high in fructose showed an increased proteintyrosine phosphatase 1B (PTP1B) content with strong expression of SREBP-1 mRNA in the liver. Fructose protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus
3 We demonstrate here a unique serial activation of the PTP1B-PP2A axis as a novel mechanism for the regulation of gene expression in the biosynthesis of triglyceride. Triglycerides protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus