Pub. Date : 2003 Sep
PMID : 12939597
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver. | Ethanol | phosphatase and tensin homolog | Rattus norvegicus |
| 2 | These effects of ethanol were associated with reduced levels of tyrosyl phosphorylated (PY) IRS-1 and PI3 kinase, Akt kinase, and Erk MAPK activities and increased levels of phosphatase tensin homologue deleted on chromosome 10 (PTEN) mRNA, protein, and phosphatase activity in liver tissue. | Ethanol | phosphatase and tensin homolog | Rattus norvegicus |
| 3 | In vitro experiments demonstrated that ethanol increases PTEN expression and function in hepatocytes. | Ethanol | phosphatase and tensin homolog | Rattus norvegicus |
| 4 | In conclusion, chronic ethanol exposure impairs survival mechanisms in the liver because of inhibition of signaling through PI3 kinase and Akt and increased levels of PTEN. | Ethanol | phosphatase and tensin homolog | Rattus norvegicus |
| 5 | However, uncoupling of the signaling cascade downstream of PTEN that mediates apoptosis may account for the relatively modest degrees of ongoing cell loss observed in livers of chronic ethanol-fed rats. | Ethanol | phosphatase and tensin homolog | Rattus norvegicus |