Title : Deacetylase activity is required for cAMP activation of a subset of CREB target genes.

Pub. Date : 2003 Oct 31

PMID : 12939274






2 Functional Relationships(s)
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1 We then tested the role of histone deacetylase activity in cAMP activation of four of these genes (c-FOS, ICER, NOR-1, and NUR77) by treating cells with the histone deacetylase inhibitor trichostatin A. trichostatin A nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus
2 Consistent with the generally accepted model, trichostatin A enhanced activation of c-FOS and NUR77 by cAMP. trichostatin A nuclear receptor subfamily 4, group A, member 1 Rattus norvegicus