Title : Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB.

Pub. Date : 2003 Jun

PMID : 12870650






8 Functional Relationships(s)
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1 Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB. Silicon Dioxide v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus
2 Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB. Tyrosine v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus
3 Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS. Tyrosine v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus
4 Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS. Silicon Dioxide v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus
5 Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS. pervanadate v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus
6 Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS. Wortmannin v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus
7 Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB. Tyrosine v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus
8 Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB. Tyrosine v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus