Pub. Date : 2003 Jun
PMID : 12870650
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB. | Silicon Dioxide | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
2 | Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB. | Tyrosine | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
3 | Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS. | Tyrosine | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
4 | Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS. | Silicon Dioxide | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
5 | Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS. | pervanadate | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
6 | Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS. | Wortmannin | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
7 | Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB. | Tyrosine | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
8 | Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB. | Tyrosine | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |