PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12870650-0	2003	Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB.	Silicon Dioxide	44-50	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	193-206	
12870650-0	2003	Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB.	Tyrosine	165-173	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	193-206	
12870650-2	2003	Results indicate that PI3-kinase activity was increased in response to silica.	Silicon Dioxide	71-77	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	22-25	
12870650-3	2003	The p85alpha subunit of PI3-kinase interacted with tyrosine-phosphorylated I(kappa)B-alpha in silica-stimulated cells.	Tyrosine	51-59	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	24-27	
12870650-3	2003	The p85alpha subunit of PI3-kinase interacted with tyrosine-phosphorylated I(kappa)B-alpha in silica-stimulated cells.	Silicon Dioxide	94-100	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	24-27	
12870650-4	2003	PI3-kinase specific inhibitors, such as wortmannin and LY294003, substantially blocked both silica-induced PI3-kinase and NF-kappaB activation.	Wortmannin	40-50	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	0-3	
12870650-4	2003	PI3-kinase specific inhibitors, such as wortmannin and LY294003, substantially blocked both silica-induced PI3-kinase and NF-kappaB activation.	Wortmannin	40-50	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	107-110	
12870650-4	2003	PI3-kinase specific inhibitors, such as wortmannin and LY294003, substantially blocked both silica-induced PI3-kinase and NF-kappaB activation.	ly294003	55-63	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	0-3	
12870650-4	2003	PI3-kinase specific inhibitors, such as wortmannin and LY294003, substantially blocked both silica-induced PI3-kinase and NF-kappaB activation.	ly294003	55-63	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	107-110	
12870650-4	2003	PI3-kinase specific inhibitors, such as wortmannin and LY294003, substantially blocked both silica-induced PI3-kinase and NF-kappaB activation.	Silicon Dioxide	92-98	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	0-3	
12870650-4	2003	PI3-kinase specific inhibitors, such as wortmannin and LY294003, substantially blocked both silica-induced PI3-kinase and NF-kappaB activation.	Silicon Dioxide	92-98	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	107-110	
12870650-5	2003	The inhibition of NF-KB activation by PI3-kinase inhibitors was also observed in pervanadate-stimulated but not in LPS-stimulated cells.	pervanadate	81-92	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	38-41	
12870650-6	2003	Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS.	Tyrosine	13-21	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	51-54	
12870650-6	2003	Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS.	Silicon Dioxide	93-99	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	51-54	
12870650-6	2003	Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS.	pervanadate	101-112	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	51-54	
12870650-6	2003	Furthermore, tyrosine phosphorylation of NF-kappaB p65 was enhanced in cells stimulated with silica, pervanadate or LPS, and wortmannin substantially inhibited the phosphorylation event induced by the first two stimulants but not LPS.	Wortmannin	125-135	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	51-54	
12870650-7	2003	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC), blocked silica-induced PI3-kinase activation, suggesting that reactive oxygen species may be important regulatory molecules in NF-kappaB activation by mediating PI3-kinase activation.	Acetylcysteine	68-71	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	136-139	
12870650-7	2003	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC), blocked silica-induced PI3-kinase activation, suggesting that reactive oxygen species may be important regulatory molecules in NF-kappaB activation by mediating PI3-kinase activation.	pyrrolidine dithiocarbamic acid	77-104	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	136-139	
12870650-7	2003	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC), blocked silica-induced PI3-kinase activation, suggesting that reactive oxygen species may be important regulatory molecules in NF-kappaB activation by mediating PI3-kinase activation.	pyrrolidine dithiocarbamic acid	106-110	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	136-139	
12870650-7	2003	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC), blocked silica-induced PI3-kinase activation, suggesting that reactive oxygen species may be important regulatory molecules in NF-kappaB activation by mediating PI3-kinase activation.	Silicon Dioxide	121-127	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	136-139	
12870650-7	2003	Antioxidants, such as superoxide dismutase (SOD), N-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC), blocked silica-induced PI3-kinase activation, suggesting that reactive oxygen species may be important regulatory molecules in NF-kappaB activation by mediating PI3-kinase activation.	Silicon Dioxide	121-127	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	274-277	
12870650-8	2003	Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB.	Tyrosine	119-127	extracellular matrix protein 1	Mus musculus	22-25	
12870650-8	2003	Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB.	Tyrosine	119-127	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	47-50	
12870650-8	2003	Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB.	Tyrosine	119-127	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	207-220	
12870650-8	2003	Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB.	Tyrosine	179-187	extracellular matrix protein 1	Mus musculus	22-25	
12870650-8	2003	Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB.	Tyrosine	179-187	serine (or cysteine) peptidase inhibitor, clade A, member 1C	Mus musculus	47-50	
12870650-8	2003	Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB.	Tyrosine	179-187	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	207-220