Pub. Date : 2003 Oct
PMID : 12837856
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this present study we investigated the effect of several HIV protease inhibitors (ABT-378, Amprenavir, Indinavir, Nelfinavir, Ritonavir, and Saquinavir) on mRNA, protein, and functional levels of LDLR family members. | Nelfinavir | low density lipoprotein receptor | Homo sapiens |
| 2 | Our results demonstrate that one of these drugs, Nelfinavir, significantly decreases LDLR and LDLR-related protein (LRP) mRNA and protein levels, resulting in the reduced functional activity of these two receptors. | Nelfinavir | low density lipoprotein receptor | Homo sapiens |
| 3 | Our results demonstrate that one of these drugs, Nelfinavir, significantly decreases LDLR and LDLR-related protein (LRP) mRNA and protein levels, resulting in the reduced functional activity of these two receptors. | Nelfinavir | LDL receptor related protein 1 | Homo sapiens |
| 4 | Our results demonstrate that one of these drugs, Nelfinavir, significantly decreases LDLR and LDLR-related protein (LRP) mRNA and protein levels, resulting in the reduced functional activity of these two receptors. | Nelfinavir | LDL receptor related protein 1 | Homo sapiens |
| 5 | Nelfinavir exerts its effect by reducing levels of active SREBP1 in the nucleus. | Nelfinavir | sterol regulatory element binding transcription factor 1 | Homo sapiens |
| 6 | The finding that Nelfinavir reduces the levels of two key receptors (LRP and LDLR) involved in lipoprotein catabolism and maintenance of vessel wall integrity identifies a mechanism that causes hypercholesterolemia complications in HIV patients treated with this drug and raises concerns about the atherogenic nature of Nelfinavir. | Nelfinavir | LDL receptor related protein 1 | Homo sapiens |
| 7 | The finding that Nelfinavir reduces the levels of two key receptors (LRP and LDLR) involved in lipoprotein catabolism and maintenance of vessel wall integrity identifies a mechanism that causes hypercholesterolemia complications in HIV patients treated with this drug and raises concerns about the atherogenic nature of Nelfinavir. | Nelfinavir | low density lipoprotein receptor | Homo sapiens |
| 8 | The finding that Nelfinavir reduces the levels of two key receptors (LRP and LDLR) involved in lipoprotein catabolism and maintenance of vessel wall integrity identifies a mechanism that causes hypercholesterolemia complications in HIV patients treated with this drug and raises concerns about the atherogenic nature of Nelfinavir. | Nelfinavir | LDL receptor related protein 1 | Homo sapiens |
| 9 | The finding that Nelfinavir reduces the levels of two key receptors (LRP and LDLR) involved in lipoprotein catabolism and maintenance of vessel wall integrity identifies a mechanism that causes hypercholesterolemia complications in HIV patients treated with this drug and raises concerns about the atherogenic nature of Nelfinavir. | Nelfinavir | low density lipoprotein receptor | Homo sapiens |