Title : FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death.

Pub. Date : 2003 Jun 27

PMID : 12837242






2 Functional Relationships(s)
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1 The FK506 binding protein (FKBP12.6) stabilizes RyR2, preventing aberrant activation of the channel during the resting phase of the cardiac cycle. Tacrolimus FKBP prolyl isomerase 1B Homo sapiens
2 We show that during exercise, RyR2 phosphorylation by cAMP-dependent protein kinase A (PKA) partially dissociates FKBP12.6 from the channel, increasing intracellular Ca(2+) release and cardiac contractility. Cyclic AMP FKBP prolyl isomerase 1B Homo sapiens