Pub. Date : 2003 Jun 27
PMID : 12837242
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The FK506 binding protein (FKBP12.6) stabilizes RyR2, preventing aberrant activation of the channel during the resting phase of the cardiac cycle. | Tacrolimus | FKBP prolyl isomerase 1B | Homo sapiens |
2 | We show that during exercise, RyR2 phosphorylation by cAMP-dependent protein kinase A (PKA) partially dissociates FKBP12.6 from the channel, increasing intracellular Ca(2+) release and cardiac contractility. | Cyclic AMP | FKBP prolyl isomerase 1B | Homo sapiens |