Title : Effects of proinsulin C-peptide in experimental diabetic neuropathy: vascular actions and modulation by nitric oxide synthase inhibition.

Pub. Date : 2003 Jul

PMID : 12829651






3 Functional Relationships(s)
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1 This could be due to a direct action on nerve fibers or via vascular mechanisms as C-peptide stimulates the nitric oxide (NO) system and NO-mediated vasodilation could potentially account for any beneficial C-peptide effects. Nitric Oxide insulin 2 Rattus norvegicus
2 L-NNA abolished C-peptide effects on nerve conduction. Nitroarginine insulin 2 Rattus norvegicus
3 C-peptide partially (57-66%) corrected these defects, an effect markedly attenuated by L-NNA co-treatment. Nitroarginine insulin 2 Rattus norvegicus