Pub. Date : 2003 Aug 1
PMID : 12723971
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | L-Buthionine-( S, R )-sulphoximine, which decreases intracellular glutathione content, enhanced glucose deprivation-induced activation of JNK1 by promoting the dissociation of TRX, but not GRX, from ASK1. | l-buthionine-( s, r )-sulphoximine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 2 | L-Buthionine-( S, R )-sulphoximine, which decreases intracellular glutathione content, enhanced glucose deprivation-induced activation of JNK1 by promoting the dissociation of TRX, but not GRX, from ASK1. | Glucose | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 3 | Treatment of cells with exogenous glutathione disulphide ester resulted in the dissociation of GRX, but not TRX, from ASK1 and the subsequent activation of JNK1. | glutathione disulphide ester | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 4 | Taken together, glucose deprivation-induced metabolic oxidative stress may activate ASK1 through two different pathways: glutathione-dependent GRX-ASK1 and glutathione-independent TRX-ASK1 pathways. | Glucose | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 5 | Taken together, glucose deprivation-induced metabolic oxidative stress may activate ASK1 through two different pathways: glutathione-dependent GRX-ASK1 and glutathione-independent TRX-ASK1 pathways. | Glutathione | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 6 | Taken together, glucose deprivation-induced metabolic oxidative stress may activate ASK1 through two different pathways: glutathione-dependent GRX-ASK1 and glutathione-independent TRX-ASK1 pathways. | Glutathione | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |