Pub. Date : 2003 Apr
PMID : 12713636
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we investigate the role of the alpha4 nicotinic acetylcholine receptor (nAChR) subunit in mediating the effects of nicotine in the mesolimbic dopamine system in mice lacking the alpha4 subunit. | Nicotine | immunoglobulin (CD79A) binding protein 1 | Mus musculus |
| 2 | Here we investigate the role of the alpha4 nicotinic acetylcholine receptor (nAChR) subunit in mediating the effects of nicotine in the mesolimbic dopamine system in mice lacking the alpha4 subunit. | Dopamine | immunoglobulin (CD79A) binding protein 1 | Mus musculus |
| 3 | Non-alpha4 subunit-containing nAChRs are located on dopaminergic neurons, are functional and respond to nicotine as demonstrated by patch clamp recordings. | Nicotine | immunoglobulin (CD79A) binding protein 1 | Mus musculus |
| 4 | Despite the fact that both wild-type and alpha4 null mutant mice show a similar increase in dopamine release in response to intrastriatal KCl perfusion, a nicotine-elicited increase in dopamine levels is not observed in mutant mice. | Dopamine | immunoglobulin (CD79A) binding protein 1 | Mus musculus |
| 5 | Despite the fact that both wild-type and alpha4 null mutant mice show a similar increase in dopamine release in response to intrastriatal KCl perfusion, a nicotine-elicited increase in dopamine levels is not observed in mutant mice. | Potassium Chloride | immunoglobulin (CD79A) binding protein 1 | Mus musculus |
| 6 | Despite the fact that both wild-type and alpha4 null mutant mice show a similar increase in dopamine release in response to intrastriatal KCl perfusion, a nicotine-elicited increase in dopamine levels is not observed in mutant mice. | Nicotine | immunoglobulin (CD79A) binding protein 1 | Mus musculus |
| 7 | Our results indicate that alpha4-containing nAChRs exert a tonic control on striatal basal dopamine release, which is mediated by a heterogeneous population of nAChRs. | Dopamine | immunoglobulin (CD79A) binding protein 1 | Mus musculus |