PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12713636-2 2003 Here we investigate the role of the alpha4 nicotinic acetylcholine receptor (nAChR) subunit in mediating the effects of nicotine in the mesolimbic dopamine system in mice lacking the alpha4 subunit. Nicotine 120-128 immunoglobulin (CD79A) binding protein 1 Mus musculus 36-42 12713636-2 2003 Here we investigate the role of the alpha4 nicotinic acetylcholine receptor (nAChR) subunit in mediating the effects of nicotine in the mesolimbic dopamine system in mice lacking the alpha4 subunit. Dopamine 147-155 immunoglobulin (CD79A) binding protein 1 Mus musculus 36-42 12713636-5 2003 Non-alpha4 subunit-containing nAChRs are located on dopaminergic neurons, are functional and respond to nicotine as demonstrated by patch clamp recordings. Nicotine 104-112 immunoglobulin (CD79A) binding protein 1 Mus musculus 4-10 12713636-7 2003 Despite the fact that both wild-type and alpha4 null mutant mice show a similar increase in dopamine release in response to intrastriatal KCl perfusion, a nicotine-elicited increase in dopamine levels is not observed in mutant mice. Dopamine 92-100 immunoglobulin (CD79A) binding protein 1 Mus musculus 41-47 12713636-7 2003 Despite the fact that both wild-type and alpha4 null mutant mice show a similar increase in dopamine release in response to intrastriatal KCl perfusion, a nicotine-elicited increase in dopamine levels is not observed in mutant mice. Potassium Chloride 138-141 immunoglobulin (CD79A) binding protein 1 Mus musculus 41-47 12713636-7 2003 Despite the fact that both wild-type and alpha4 null mutant mice show a similar increase in dopamine release in response to intrastriatal KCl perfusion, a nicotine-elicited increase in dopamine levels is not observed in mutant mice. Nicotine 155-163 immunoglobulin (CD79A) binding protein 1 Mus musculus 41-47 12713636-11 2003 Our results indicate that alpha4-containing nAChRs exert a tonic control on striatal basal dopamine release, which is mediated by a heterogeneous population of nAChRs. Dopamine 91-99 immunoglobulin (CD79A) binding protein 1 Mus musculus 26-32