Title : Glucose regulates insulin gene transcription by hyperacetylation of histone h4.

Pub. Date : 2003 May 30

PMID : 12665509






3 Functional Relationships(s)
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1 Although several transcription factors including Beta-2, Ribe3b1, and Pdx-1 have been shown to play a role in glucose stimulation of insulin gene expression, the exact molecular mechanism(s) by which this regulation occurs is unknown. Glucose neurogenic differentiation 1 Mus musculus
2 Previous data demonstrate that the transcription factors Beta-2/NeuroD1 and Pdx-1, which are involved in glucose-stimulated insulin gene expression, interact with the histone acetylase p300, suggesting a role for histone acetylation in glucose regulation of the insulin gene expression. Glucose neurogenic differentiation 1 Mus musculus
3 Previous data demonstrate that the transcription factors Beta-2/NeuroD1 and Pdx-1, which are involved in glucose-stimulated insulin gene expression, interact with the histone acetylase p300, suggesting a role for histone acetylation in glucose regulation of the insulin gene expression. Glucose neurogenic differentiation 1 Mus musculus