Title : Structure-activity study of LVV-hemorphin-7: angiotensin AT4 receptor ligand and inhibitor of insulin-regulated aminopeptidase.

Pub. Date : 2003 Apr

PMID : 12649370






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 All LVV-hemorphin-7 analogs tested, except for Leu-Val-Val-Tyr, inhibit the cleavage of the synthetic substrate, leucine beta-naphthylamide, by IRAP, with K(i) values between 56 and 620 nM. leu-val-val-tyr leucyl and cystinyl aminopeptidase Homo sapiens
2 All LVV-hemorphin-7 analogs tested, except for Leu-Val-Val-Tyr, inhibit the cleavage of the synthetic substrate, leucine beta-naphthylamide, by IRAP, with K(i) values between 56 and 620 nM. leucine-beta-naphthylamide leucyl and cystinyl aminopeptidase Homo sapiens
3 We find that the Val(3) residue is crucial for LVV-hemorphin-7 binding to IRAP, whereas the C-terminal domain seems to play a minor role. Valine leucyl and cystinyl aminopeptidase Homo sapiens