Pub. Date : 2003 Feb
PMID : 12624816
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The depressor and vasodilator effects of rutaecarpine are mediated by calcitonin gene-related peptide. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 2 | Previous studies have shown that rutaecarpine has depressor and vasodilator effects, and activates vanilloid receptors to evoke calcitonin gene-related peptide (CGRP) release. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 3 | Previous studies have shown that rutaecarpine has depressor and vasodilator effects, and activates vanilloid receptors to evoke calcitonin gene-related peptide (CGRP) release. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 4 | In the present study, we examined whether the depressor and vasodilator effects of rutaecarpine are related to the stimulation of endogenous CGRP release via activation of vanilloid receptors in rats. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 5 | Rutaecarpine (30, 100, or 300 microg/kg, i. v.) caused a depressor effect concomitantly with an increase in the plasma concentrations of CGRP in a dose-dependent manner, and the effects of rutaecarpine were abolished by pretreatment with capsaicin (50 mg/kg, s. c.) which depletes neurotransmitters in sensory nerves. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 6 | In aortic and superior mesenteric arterial rings, rutaecarpine (10 (-7)-10(-5) M) or capsaicin (3 x 10(-9)-3 x 10(-6) M) caused a concentration-dependent vasodilator response, which was significantly attenuated by capsazepine (10(-5) M), a competitive vanilloid receptor antagonist, or by CGRP-(8-37) (10(-6) M), a selective CGRP receptor antagonist. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 7 | In aortic and superior mesenteric arterial rings, rutaecarpine (10 (-7)-10(-5) M) or capsaicin (3 x 10(-9)-3 x 10(-6) M) caused a concentration-dependent vasodilator response, which was significantly attenuated by capsazepine (10(-5) M), a competitive vanilloid receptor antagonist, or by CGRP-(8-37) (10(-6) M), a selective CGRP receptor antagonist. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 8 | These results suggest that the depressor and vasodilator effects of rutaecarpine are related to stimulation of endogenous CGRP release via activation of vanilloid receptors in rats. | rutecarpine | calcitonin-related polypeptide alpha | Rattus norvegicus |