Pub. Date : 2003 Feb 18
PMID : 12578987
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Analysis of the patient"s P2Y(12) gene revealed a G-to-A transition in one allele, changing the codon for Arg-256 in the sixth transmembrane domain to Gln, and a C-to-T transition in the other allele, changing the codon for Arg-265 in the third extracellular loop to Trp. | Arginine | purinergic receptor P2Y12 | Homo sapiens |
| 2 | Analysis of the patient"s P2Y(12) gene revealed a G-to-A transition in one allele, changing the codon for Arg-256 in the sixth transmembrane domain to Gln, and a C-to-T transition in the other allele, changing the codon for Arg-265 in the third extracellular loop to Trp. | Glutamine | purinergic receptor P2Y12 | Homo sapiens |
| 3 | Analysis of the patient"s P2Y(12) gene revealed a G-to-A transition in one allele, changing the codon for Arg-256 in the sixth transmembrane domain to Gln, and a C-to-T transition in the other allele, changing the codon for Arg-265 in the third extracellular loop to Trp. | Arginine | purinergic receptor P2Y12 | Homo sapiens |
| 4 | Analysis of the patient"s P2Y(12) gene revealed a G-to-A transition in one allele, changing the codon for Arg-256 in the sixth transmembrane domain to Gln, and a C-to-T transition in the other allele, changing the codon for Arg-265 in the third extracellular loop to Trp. | Tryptophan | purinergic receptor P2Y12 | Homo sapiens |
| 5 | Neither mutation interfered with receptor surface expression but both altered function, since ADP inhibited the forskolin-induced increase of cAMP markedly less in cells transfected with either mutant P2Y(12) as compared with wild-type receptor. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
| 6 | Neither mutation interfered with receptor surface expression but both altered function, since ADP inhibited the forskolin-induced increase of cAMP markedly less in cells transfected with either mutant P2Y(12) as compared with wild-type receptor. | Colforsin | purinergic receptor P2Y12 | Homo sapiens |
| 7 | Neither mutation interfered with receptor surface expression but both altered function, since ADP inhibited the forskolin-induced increase of cAMP markedly less in cells transfected with either mutant P2Y(12) as compared with wild-type receptor. | Cyclic AMP | purinergic receptor P2Y12 | Homo sapiens |
| 8 | These studies delineate a region of P2Y(12) required for normal function after ADP binding. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |