Title : Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder.

Pub. Date : 2003 Feb

PMID : 12555229






4 Functional Relationships(s)
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1 Remarkably, a single conserved LDHA exon 5 haplotype conferred increased risk for a paradoxical ventilatory response pattern to CO(2) inhalation which robustly separated well subjects at high risk for PD from low-risk control subjects. co(2) lactate dehydrogenase A Homo sapiens
2 Given the pivotal role of LDH in the metabolism of lactate, a known inducer of panic attacks, and the dependence of LDH activity on cell pH, we suggest that LDHA polymorphisms may contribute to the variability to CO(2) respiratory challenge. Lactic Acid lactate dehydrogenase A Homo sapiens
3 Given the pivotal role of LDH in the metabolism of lactate, a known inducer of panic attacks, and the dependence of LDH activity on cell pH, we suggest that LDHA polymorphisms may contribute to the variability to CO(2) respiratory challenge. co(2) lactate dehydrogenase A Homo sapiens
4 Given the pivotal role of LDH in the metabolism of lactate, a known inducer of panic attacks, and the dependence of LDH activity on cell pH, we suggest that LDHA polymorphisms may contribute to the variability to CO(2) respiratory challenge. co(2) lactate dehydrogenase A Homo sapiens