Pub. Date : 2003 Mar 14
PMID : 12514175
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways. | Potassium | growth differentiation factor 15 | Homo sapiens | ||
| 2 | In contrast, mitogen-activated protein kinase (MEK)/extracellular-signal-regulated kinase (ERK) pathway inhibitors U0126 and PD98059 potentiated GDF-15 mediated survival and prevented cell death in low K(+) even without factor treatment. | U 0126 | growth differentiation factor 15 | Homo sapiens | ||
| 3 | In contrast, mitogen-activated protein kinase (MEK)/extracellular-signal-regulated kinase (ERK) pathway inhibitors U0126 and PD98059 potentiated GDF-15 mediated survival and prevented cell death in low K(+) even without factor treatment. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | growth differentiation factor 15 | Homo sapiens | ||
| 4 | Furthermore, we show that GDF-15 prevented generation of reactive oxygen species, a known activator of ERK. | Reactive Oxygen Species | growth differentiation factor 15 | Homo sapiens | ||