Title : Effect of caffeine on acetaminophen hepatotoxicity in cultured hepatocytes treated with ethanol and isopentanol.

Pub. Date : 2002 Dec 1

PMID : 12490133






1 Functional Relationships(s)
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1 Pretreatment of cultured rat hepatocytes with ethanol alone or in combination with isopentanol, the major higher chain alcohol in alcoholic beverages, significantly increased CYP3A and acetaminophen (APAP) bioactivation, with no increase in APAP toxicity. isopentyl alcohol cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus