Pub. Date : 2002 Dec
PMID : 12435803
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stimulation of D(2)DR induced a 60% inhibition in protein tyrosine phosphatase (PTP) activity but not in PSP activity in lesioned striata. | Tyrosine | protein tyrosine phosphatase, non-receptor type 1 | Rattus norvegicus |
| 2 | The D(2)DR antagonist spiperone blocked quinpirole-elicited PTP inhibition, and the D(1) receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SKF38393) did not inhibit PTP activity, indicating that PTP inhibition is a specific effect mediated by stimulation of D(2)DR. We further discovered that striatal mitogen-activated protein kinase phosphatase (MKP), a protein phosphatase that is responsible for ERK dephosphorylation, is inhibited in response to D(2)DR stimulation in 6-OHDA-lesioned rats. | Spiperone | protein tyrosine phosphatase, non-receptor type 1 | Rattus norvegicus |
| 3 | The D(2)DR antagonist spiperone blocked quinpirole-elicited PTP inhibition, and the D(1) receptor agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (SKF38393) did not inhibit PTP activity, indicating that PTP inhibition is a specific effect mediated by stimulation of D(2)DR. We further discovered that striatal mitogen-activated protein kinase phosphatase (MKP), a protein phosphatase that is responsible for ERK dephosphorylation, is inhibited in response to D(2)DR stimulation in 6-OHDA-lesioned rats. | Quinpirole | protein tyrosine phosphatase, non-receptor type 1 | Rattus norvegicus |
| 4 | The results indicate that 6-OHDA-induced striatal denervation leads to abnormal coupling between D(2)DR and PTP/MKP pathway. | Oxidopamine | protein tyrosine phosphatase, non-receptor type 1 | Rattus norvegicus |
| 5 | Moreover, unilateral inhibition of striatal PTP by an intrastriatal injection of vanadate induced contralateral rotation in control rats in response to D(2)DR stimulation, thus mimicking the response observed in the unilateral 6-OHDA-lesioned rat. | Vanadates | protein tyrosine phosphatase, non-receptor type 1 | Rattus norvegicus |
| 6 | Moreover, unilateral inhibition of striatal PTP by an intrastriatal injection of vanadate induced contralateral rotation in control rats in response to D(2)DR stimulation, thus mimicking the response observed in the unilateral 6-OHDA-lesioned rat. | Oxidopamine | protein tyrosine phosphatase, non-receptor type 1 | Rattus norvegicus |