Pub. Date : 2002 Nov 18
PMID : 12406645
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Functionally, microsomes from a CYP3A5*3/*3 liver contain very low CYP3A5 protein and display on average reduced catalytic activity towards midazolam. | Midazolam | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | As CYP3A5 is the primary extrahepatic CYP3A isoform, its polymorphic expression may be implicated in disease risk and the metabolism of endogenous steroids or xenobiotics in these tissues (e.g., lung, kidney, prostate, breast, leukocytes). | Steroids | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |