Title : Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21.

Pub. Date : 2002 Oct 10

PMID : 12370832






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. Hydrogen beta-secretase 2 Homo sapiens
2 Thr18 phosphorylation has been shown to abolish side-chain hydrogen bonding between Thr18 and Asp21, an interaction necessary for stabilizing alpha-helical conformation within the transactivation domain. UNII-PYZ33YLR8A beta-secretase 2 Homo sapiens
3 Thr18 phosphorylation has been shown to abolish side-chain hydrogen bonding between Thr18 and Asp21, an interaction necessary for stabilizing alpha-helical conformation within the transactivation domain. Hydrogen beta-secretase 2 Homo sapiens
4 We conclude disruption of intramolecular hydrogen bonding between Thr18 and Asp21 enhances p53 transactivation by modulating Mdm-2 binding, facilitating TAF(II)31 recruitment. Hydrogen beta-secretase 2 Homo sapiens