Pub. Date : 2002 Oct 10
PMID : 12370832
4 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. | Hydrogen | beta-secretase 2 | Homo sapiens | ||
2 | Thr18 phosphorylation has been shown to abolish side-chain hydrogen bonding between Thr18 and Asp21, an interaction necessary for stabilizing alpha-helical conformation within the transactivation domain. | UNII-PYZ33YLR8A | beta-secretase 2 | Homo sapiens | ||
3 | Thr18 phosphorylation has been shown to abolish side-chain hydrogen bonding between Thr18 and Asp21, an interaction necessary for stabilizing alpha-helical conformation within the transactivation domain. | Hydrogen | beta-secretase 2 | Homo sapiens | ||
4 | We conclude disruption of intramolecular hydrogen bonding between Thr18 and Asp21 enhances p53 transactivation by modulating Mdm-2 binding, facilitating TAF(II)31 recruitment. | Hydrogen | beta-secretase 2 | Homo sapiens |