Title : Effect of coadministration of nelfinavir, indinavir, and saquinavir on the pharmacokinetics of amprenavir.

Pub. Date : 2002 Aug

PMID : 12189360






1 Functional Relationships(s)
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1 The absolute magnitude of amprenavir intrinsic clearance suggests that CYP3A4 inhibition by nelfinavir and indinavir is balanced by enzymatic induction in the presence of the background drug(s), most likely efavirenz. Nelfinavir cytochrome P450 family 3 subfamily A member 4 Homo sapiens