Pub. Date : 2002 Jul
PMID : 12089367
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro, the oxygen-regulated subunits HIF-1alpha and -2alpha are expressed in inverse relationship to oxygen tensions in every cell line investigated to date. | Oxygen | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 2 | In vitro, the oxygen-regulated subunits HIF-1alpha and -2alpha are expressed in inverse relationship to oxygen tensions in every cell line investigated to date. | Oxygen | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 3 | High-amplification immunohistochemical analyses were used to study the expression of HIF-1alpha and -2alpha in kidneys of rats exposed to systemic hypoxia bleeding anemia, functional anemia (0.1% carbon monoxide), renal ischemia, or cobaltous chloride (which is known to mimic hypoxia). | Carbon Monoxide | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 4 | High-amplification immunohistochemical analyses were used to study the expression of HIF-1alpha and -2alpha in kidneys of rats exposed to systemic hypoxia bleeding anemia, functional anemia (0.1% carbon monoxide), renal ischemia, or cobaltous chloride (which is known to mimic hypoxia). | cobaltous chloride | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 5 | HIF-1alpha was mainly induced in tubular cells, including proximal segments with exposure to anemia/carbon monoxide, in distal segments with cobaltous chloride treatment, and in connecting tubules and collecting ducts with all stimuli. | Carbon Monoxide | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 6 | HIF-1alpha was mainly induced in tubular cells, including proximal segments with exposure to anemia/carbon monoxide, in distal segments with cobaltous chloride treatment, and in connecting tubules and collecting ducts with all stimuli. | Chlorides | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |
| 7 | The kidney demonstrates a marked potential for upregulation of HIF, but accumulation of HIF-1alpha and HIF-2alpha is selective with respect to cell type, kidney zone, and experimental conditions, with the expression patterns partly matching known oxygen profiles. | Oxygen | hypoxia inducible factor 1 subunit alpha | Rattus norvegicus |