Title : MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenated species.

Pub. Date : 2002 Aug 16

PMID : 12052825






5 Functional Relationships(s)
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Protein Name
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1 A scavenger of reactive oxygenated species (ROS), N-acetylcysteine (NAC) at 20 mm, completely suppresses the activation of MAP kinases and ASK1, suggesting a role for oxidative stress in the activation mechanism. reactive oxygenated species mitogen-activated protein kinase kinase kinase 5 Homo sapiens
2 A scavenger of reactive oxygenated species (ROS), N-acetylcysteine (NAC) at 20 mm, completely suppresses the activation of MAP kinases and ASK1, suggesting a role for oxidative stress in the activation mechanism. ros mitogen-activated protein kinase kinase kinase 5 Homo sapiens
3 A scavenger of reactive oxygenated species (ROS), N-acetylcysteine (NAC) at 20 mm, completely suppresses the activation of MAP kinases and ASK1, suggesting a role for oxidative stress in the activation mechanism. Acetylcysteine mitogen-activated protein kinase kinase kinase 5 Homo sapiens
4 A scavenger of reactive oxygenated species (ROS), N-acetylcysteine (NAC) at 20 mm, completely suppresses the activation of MAP kinases and ASK1, suggesting a role for oxidative stress in the activation mechanism. Acetylcysteine mitogen-activated protein kinase kinase kinase 5 Homo sapiens
5 Ciglitazone (20 microm), a thiazolidinedione that mimics several effects of dPGJ2 in different cell types, also activates the three MAP kinase families and ASK1 in cultured astrocytes. ciglitazone mitogen-activated protein kinase kinase kinase 5 Homo sapiens