PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12052825-0	2002	MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenated species.	thiazolidinedione ciglitazone	118-147	peroxisome proliferator activated receptor gamma	Homo sapiens	156-204	
12052825-0	2002	MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxygenated species.	species	258-265	peroxisome proliferator activated receptor gamma	Homo sapiens	156-204	
12052825-1	2002	15-Deoxy-Delta(12-14)-prostaglandin J(2) (dPGJ2) and thiazolidinediones are known as ligands for the peroxisome proliferator activator receptor gamma (PPAR gamma) a member of the nuclear receptor superfamily.	15-deoxy-delta(12,14)-prostaglandin J2	0-40	peroxisome proliferator activated receptor gamma	Homo sapiens	101-149	
12052825-1	2002	15-Deoxy-Delta(12-14)-prostaglandin J(2) (dPGJ2) and thiazolidinediones are known as ligands for the peroxisome proliferator activator receptor gamma (PPAR gamma) a member of the nuclear receptor superfamily.	15-deoxy-delta(12,14)-prostaglandin J2	0-40	peroxisome proliferator activated receptor gamma	Homo sapiens	151-161	
12052825-1	2002	15-Deoxy-Delta(12-14)-prostaglandin J(2) (dPGJ2) and thiazolidinediones are known as ligands for the peroxisome proliferator activator receptor gamma (PPAR gamma) a member of the nuclear receptor superfamily.	15-deoxy-delta(12,14)-prostaglandin J2	42-47	peroxisome proliferator activated receptor gamma	Homo sapiens	101-149	
12052825-1	2002	15-Deoxy-Delta(12-14)-prostaglandin J(2) (dPGJ2) and thiazolidinediones are known as ligands for the peroxisome proliferator activator receptor gamma (PPAR gamma) a member of the nuclear receptor superfamily.	15-deoxy-delta(12,14)-prostaglandin J2	42-47	peroxisome proliferator activated receptor gamma	Homo sapiens	151-161	
12052825-1	2002	15-Deoxy-Delta(12-14)-prostaglandin J(2) (dPGJ2) and thiazolidinediones are known as ligands for the peroxisome proliferator activator receptor gamma (PPAR gamma) a member of the nuclear receptor superfamily.	Thiazolidinediones	53-71	peroxisome proliferator activated receptor gamma	Homo sapiens	101-149	
12052825-1	2002	15-Deoxy-Delta(12-14)-prostaglandin J(2) (dPGJ2) and thiazolidinediones are known as ligands for the peroxisome proliferator activator receptor gamma (PPAR gamma) a member of the nuclear receptor superfamily.	Thiazolidinediones	53-71	peroxisome proliferator activated receptor gamma	Homo sapiens	151-161	
12052825-5	2002	A scavenger of reactive oxygenated species (ROS), N-acetylcysteine (NAC) at 20 mm, completely suppresses the activation of MAP kinases and ASK1, suggesting a role for oxidative stress in the activation mechanism.	reactive oxygenated species	15-42	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	139-143	
12052825-5	2002	A scavenger of reactive oxygenated species (ROS), N-acetylcysteine (NAC) at 20 mm, completely suppresses the activation of MAP kinases and ASK1, suggesting a role for oxidative stress in the activation mechanism.	ros	44-47	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	139-143	
12052825-5	2002	A scavenger of reactive oxygenated species (ROS), N-acetylcysteine (NAC) at 20 mm, completely suppresses the activation of MAP kinases and ASK1, suggesting a role for oxidative stress in the activation mechanism.	Acetylcysteine	50-66	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	139-143	
12052825-5	2002	A scavenger of reactive oxygenated species (ROS), N-acetylcysteine (NAC) at 20 mm, completely suppresses the activation of MAP kinases and ASK1, suggesting a role for oxidative stress in the activation mechanism.	Acetylcysteine	68-71	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	139-143	
12052825-7	2002	Ciglitazone (20 microm), a thiazolidinedione that mimics several effects of dPGJ2 in different cell types, also activates the three MAP kinase families and ASK1 in cultured astrocytes.	ciglitazone	0-11	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	156-160	
12052825-10	2002	Another thiazolidinedione that binds to PPAR gamma, rosiglitazone, does not activate MAP kinases, indicating that the effect of ciglitazone on MAP kinases is independent of PPAR gamma.	2,4-thiazolidinedione	8-25	peroxisome proliferator activated receptor gamma	Homo sapiens	40-50	
12052825-10	2002	Another thiazolidinedione that binds to PPAR gamma, rosiglitazone, does not activate MAP kinases, indicating that the effect of ciglitazone on MAP kinases is independent of PPAR gamma.	Rosiglitazone	52-65	peroxisome proliferator activated receptor gamma	Homo sapiens	40-50	
12052825-11	2002	Ciglitazone and less strongly dPGJ2 activate Erk in undifferentiated cells of the adipocyte cell line 1B8.	ciglitazone	0-11	mitogen-activated protein kinase 1	Homo sapiens	45-48	
12052825-12	2002	Ciglitazone also activates Jnk and p38 MAP kinase in these preadipocytes.	ciglitazone	0-11	mitogen-activated protein kinase 14	Homo sapiens	35-38	
12052825-13	2002	Our findings suggest that a part of the biological effects of dPGJ2 and ciglitazone involve the activation of the three MAP kinase families probably through PPAR gamma-independent mechanisms involving ROS.	15-deoxy-delta(12,14)-prostaglandin J2	62-67	peroxisome proliferator activated receptor gamma	Homo sapiens	157-167	
12052825-13	2002	Our findings suggest that a part of the biological effects of dPGJ2 and ciglitazone involve the activation of the three MAP kinase families probably through PPAR gamma-independent mechanisms involving ROS.	ciglitazone	72-83	peroxisome proliferator activated receptor gamma	Homo sapiens	157-167