Pub. Date : 2002 Apr
PMID : 11988022
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calsenilin (also called DREAM and KChIP3), a member of the neuronal calcium sensor family, was isolated in a yeast two-hybrid screen using an apoptotic domain of presenilin 2 as bait. | Calcium | potassium voltage-gated channel interacting protein 3 | Homo sapiens |
| 2 | Calsenilin (also called DREAM and KChIP3), a member of the neuronal calcium sensor family, was isolated in a yeast two-hybrid screen using an apoptotic domain of presenilin 2 as bait. | Calcium | potassium voltage-gated channel interacting protein 3 | Homo sapiens |
| 3 | Calsenilin (also called DREAM and KChIP3), a member of the neuronal calcium sensor family, was isolated in a yeast two-hybrid screen using an apoptotic domain of presenilin 2 as bait. | Calcium | potassium voltage-gated channel interacting protein 3 | Homo sapiens |
| 4 | Calsenilin is a cytoplasmic protein, but interacts with the COOH-termini of both presenilin 1 and presenilin 2 at the endoplasmic reticulum and the Golgi apparatus. | Carbonic Acid | potassium voltage-gated channel interacting protein 3 | Homo sapiens |
| 5 | In stable neuroglioma cell lines, we observed that calsenilin enhances apoptosis in response to serum withdrawal or thapsigargin. | Thapsigargin | potassium voltage-gated channel interacting protein 3 | Homo sapiens |
| 6 | Moreover, using calcium imaging we were able to show that cells treated with thapsigargin released more calcium from intracellular stores when calsenilin was overexpressed. | Calcium | potassium voltage-gated channel interacting protein 3 | Homo sapiens |
| 7 | Moreover, using calcium imaging we were able to show that cells treated with thapsigargin released more calcium from intracellular stores when calsenilin was overexpressed. | Thapsigargin | potassium voltage-gated channel interacting protein 3 | Homo sapiens |
| 8 | Moreover, using calcium imaging we were able to show that cells treated with thapsigargin released more calcium from intracellular stores when calsenilin was overexpressed. | Calcium | potassium voltage-gated channel interacting protein 3 | Homo sapiens |
| 9 | Taken together, these data suggest that calsenilin causes cells to be more susceptible to apoptotic triggers, possibly by altering calcium dynamics. | Calcium | potassium voltage-gated channel interacting protein 3 | Homo sapiens |