Title : Biochemical and molecular effects of UCN-01 in combination with 5-fluorodeoxyuridine in A431 human epidermoid cancer cells.

Pub. Date : 2002 Mar

PMID : 11984070






3 Functional Relationships(s)
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1 Concurrent and pre-exposure of A431 human epidermoid cancer cells to UCN-01, an investigational anticancer drug, with 5-fluoro--2"-deoxyuridine (FdUrd), which targets thymidylate synthase, produced more than additive cytotoxicty. 5-fluoro-2'-deoxyuridine urocortin Homo sapiens
2 Concurrent and pre-exposure of A431 human epidermoid cancer cells to UCN-01, an investigational anticancer drug, with 5-fluoro--2"-deoxyuridine (FdUrd), which targets thymidylate synthase, produced more than additive cytotoxicty. 5-fluoro-2'-deoxyuridine urocortin Homo sapiens
3 Concurrent thymidine exposure led to repletion of dTTP pools, and cytoprotection against FdUrd alone and with UCN-01. Thymidine urocortin Homo sapiens