Title : Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53.

Pub. Date : 2002 Mar

PMID : 11895857






7 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. Resveratrol growth differentiation factor 15 Homo sapiens
2 Here, we have demonstrated that resveratrol induces NAG-1 expression and apoptosis in a concentration-dependent manner. Resveratrol growth differentiation factor 15 Homo sapiens
3 Resveratrol increases the expression of p53, tumor suppressor protein, prior to NAG-1 induction, indicating that NAG-1 expression by resveratrol is mediated by p53 expression. Resveratrol growth differentiation factor 15 Homo sapiens
4 We also show that the p53 binding sites within the promoter region of NAG-1 play a pivotal role to control NAG-1 expression by resveratrol. Resveratrol growth differentiation factor 15 Homo sapiens
5 We also show that the p53 binding sites within the promoter region of NAG-1 play a pivotal role to control NAG-1 expression by resveratrol. Resveratrol growth differentiation factor 15 Homo sapiens
6 Derivatives of resveratrol were examined for NAG-1 induction, and the data suggest that resveratrol-induced NAG-1 and p53 induction is not dependent on its anti-oxidant activity. Resveratrol growth differentiation factor 15 Homo sapiens
7 Derivatives of resveratrol were examined for NAG-1 induction, and the data suggest that resveratrol-induced NAG-1 and p53 induction is not dependent on its anti-oxidant activity. Resveratrol growth differentiation factor 15 Homo sapiens