Pub. Date : 2002 Mar
PMID : 11861777
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, the involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of pravastatin was investigated. | Pravastatin | solute carrier family 22 member 8 | Rattus norvegicus |
| 2 | In the present study, the involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of pravastatin was investigated. | Pravastatin | solute carrier family 22 member 8 | Rattus norvegicus |
| 3 | rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. | p-Aminohippuric Acid | solute carrier family 22 member 8 | Rattus norvegicus |
| 4 | rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. | p-Aminohippuric Acid | solute carrier family 22 member 8 | Rattus norvegicus |
| 5 | rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. | p-Aminohippuric Acid | solute carrier family 22 member 8 | Rattus norvegicus |
| 6 | rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. | p-Aminohippuric Acid | solute carrier family 22 member 8 | Rattus norvegicus |
| 7 | rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. | Pravastatin | solute carrier family 22 member 8 | Rattus norvegicus |
| 8 | rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. | Pravastatin | solute carrier family 22 member 8 | Rattus norvegicus |
| 9 | rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. | p-Aminohippuric Acid | solute carrier family 22 member 8 | Rattus norvegicus |
| 10 | rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. | Pravastatin | solute carrier family 22 member 8 | Rattus norvegicus |
| 11 | This was also supported by the difference in the degree of inhibition by benzylpenicillin, a relatively selective inhibitor of rOat3, for the uptake of PAH and pravastatin by kidney slices. | Penicillin G | solute carrier family 22 member 8 | Rattus norvegicus |
| 12 | This was also supported by the difference in the degree of inhibition by benzylpenicillin, a relatively selective inhibitor of rOat3, for the uptake of PAH and pravastatin by kidney slices. | p-Aminohippuric Acid | solute carrier family 22 member 8 | Rattus norvegicus |
| 13 | This was also supported by the difference in the degree of inhibition by benzylpenicillin, a relatively selective inhibitor of rOat3, for the uptake of PAH and pravastatin by kidney slices. | Pravastatin | solute carrier family 22 member 8 | Rattus norvegicus |
| 14 | These results suggest that rOat1 and rOat3 are mainly responsible for the renal uptake of PAH and pravastatin, respectively. | p-Aminohippuric Acid | solute carrier family 22 member 8 | Rattus norvegicus |
| 15 | These results suggest that rOat1 and rOat3 are mainly responsible for the renal uptake of PAH and pravastatin, respectively. | Pravastatin | solute carrier family 22 member 8 | Rattus norvegicus |