Title : Effect of ramipril and furosemide treatment on interstitial remodeling in post-infarction heart failure rat hearts.

Pub. Date : 2002 Feb

PMID : 11851355






2 Functional Relationships(s)
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1 Ramipril reduced MMP-2 expression (active form), collagen type I mRNA expression and content and increased TIMP-4 levels associated with decreased left ventricular end diastolic pressure (LVEDP), mortality rate and increased LV pressure (LVP). Ramipril matrix metallopeptidase 2 Rattus norvegicus
2 Combination therapy with furosemide is less efficient with regard to collagen content and MMP-2 (active form) reduction but did not worsen beneficial effects of ramipril on LV function and mortality rate. Furosemide matrix metallopeptidase 2 Rattus norvegicus