Title : Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells.

Pub. Date : 2002 May 3

PMID : 11850418






2 Functional Relationships(s)
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1 Relative to wild-type, Xa-triggered phosphoinositide hydrolysis was reduced by 60-75% in Par2 -/- endothelial cells, by 20-30% in Par1 -/- endothelial cells, and by approximately 90% in Par2 -/- endothelial cells treated with a PAR1 antagonist. Phosphatidylinositols coagulation factor II (thrombin) receptor Mus musculus
2 By contrast, in fibroblasts, PAR1 by itself accounted for virtually all Xa-induced phosphoinositide hydrolysis. Phosphatidylinositols coagulation factor II (thrombin) receptor Mus musculus