Title : Effects of magnesium on contractile activation of skinned cardiac cells.

Pub. Date : 1975 Aug

PMID : 1177102






9 Functional Relationships(s)
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1 In the presence of a slight buffering of the free [Ca2+] with 0.050 mM total EGTA cyclic contractions were induced by a Ca2+-triggered release of Ca2+ on skinned (sarcolemma-free) segments of single cardiac cells from rat ventricle. Egtazic Acid carbonic anhydrase 2 Rattus norvegicus
2 In the presence of a slight buffering of the free [Ca2+] with 0.050 mM total EGTA cyclic contractions were induced by a Ca2+-triggered release of Ca2+ on skinned (sarcolemma-free) segments of single cardiac cells from rat ventricle. Egtazic Acid carbonic anhydrase 2 Rattus norvegicus
3 In the presence of a slight buffering of the free [Ca2+] with 0.050 mM total EGTA cyclic contractions were induced by a Ca2+-triggered release of Ca2+ on skinned (sarcolemma-free) segments of single cardiac cells from rat ventricle. Egtazic Acid carbonic anhydrase 2 Rattus norvegicus
4 The threshold of the free [Ca2+] trigger was elevated when the free [Mg2+] was increased. magnesium ion carbonic anhydrase 2 Rattus norvegicus
5 At a suprathreshold free [Ca2+] increasing the free [Mg2+] resulted in a decrease in frequency and in an increase in amplitude of the phasic contractions. magnesium ion carbonic anhydrase 2 Rattus norvegicus
6 It was concluded that an increase of free [Mg2+] increased the capacity and the rate of binding for Ca2+ by the sarcoplasmic reticulum (SR). magnesium ion carbonic anhydrase 2 Rattus norvegicus
7 With a strong buffering of the free [Ca2+] with 4-0 mM total EGTA, a smaller tonic tension was developed for a given pCa in the presence of a higher free [Mg2+]. Egtazic Acid carbonic anhydrase 2 Rattus norvegicus
8 With a strong buffering of the free [Ca2+] with 4-0 mM total EGTA, a smaller tonic tension was developed for a given pCa in the presence of a higher free [Mg2+]. magnesium ion carbonic anhydrase 2 Rattus norvegicus
9 A decrease of the [MgATP2-] produced a tension in the skinned cardiac cells that were perfused in Ca2+ free media. mgatp2 carbonic anhydrase 2 Rattus norvegicus