Pub. Date : 2002 Jan
PMID : 11709494
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High concentration of H2O2 increased an apoptotic signal molecule, ASK1, which resulted in Bcl-2 down-regulation, membrane potential disruption, decreased ATP and glucose uptake, and activation of caspases. | Glucose | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 2 | Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways. | Selenious Acid | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 3 | Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways. | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 4 | It was found that physiological concentration of selenite, 3 microM, reduced ASK1 activity and induced PI3-kinase (PI3-K)/Akt pathways in HT1080 cells. | Selenious Acid | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 5 | High concentration of H2O2 increased an apoptotic signal molecule, ASK1, which resulted in Bcl-2 down-regulation, membrane potential disruption, decreased ATP and glucose uptake, and activation of caspases. | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 6 | High concentration of H2O2 increased an apoptotic signal molecule, ASK1, which resulted in Bcl-2 down-regulation, membrane potential disruption, decreased ATP and glucose uptake, and activation of caspases. | Adenosine Triphosphate | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 7 | Selenite blocked apoptosis induced by H2O2, which was related to blocking ASK1 and further stimulating PI3-kinase/Akt activities. | Selenious Acid | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 8 | Selenite blocked apoptosis induced by H2O2, which was related to blocking ASK1 and further stimulating PI3-kinase/Akt activities. | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |