PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11709494-6	2002	High concentration of H2O2 increased an apoptotic signal molecule, ASK1, which resulted in Bcl-2 down-regulation, membrane potential disruption, decreased ATP and glucose uptake, and activation of caspases.	Glucose	163-170	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	67-71	
11709494-0	2002	Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways.	Selenious Acid	0-8	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	83-87	
11709494-0	2002	Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways.	Selenious Acid	0-8	mitogen-activated protein kinase 8	Homo sapiens	88-91	
11709494-0	2002	Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways.	Selenious Acid	0-8	AKT serine/threonine kinase 1	Homo sapiens	116-119	
11709494-0	2002	Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways.	Hydrogen Peroxide	20-37	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	83-87	
11709494-0	2002	Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways.	Hydrogen Peroxide	20-37	mitogen-activated protein kinase 8	Homo sapiens	88-91	
11709494-0	2002	Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways.	Hydrogen Peroxide	20-37	AKT serine/threonine kinase 1	Homo sapiens	116-119	
11709494-2	2002	It was found that physiological concentration of selenite, 3 microM, reduced ASK1 activity and induced PI3-kinase (PI3-K)/Akt pathways in HT1080 cells.	Selenious Acid	49-57	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	77-81	
11709494-2	2002	It was found that physiological concentration of selenite, 3 microM, reduced ASK1 activity and induced PI3-kinase (PI3-K)/Akt pathways in HT1080 cells.	Selenious Acid	49-57	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	103-113	
11709494-2	2002	It was found that physiological concentration of selenite, 3 microM, reduced ASK1 activity and induced PI3-kinase (PI3-K)/Akt pathways in HT1080 cells.	Selenious Acid	49-57	AKT serine/threonine kinase 1	Homo sapiens	122-125	
11709494-6	2002	High concentration of H2O2 increased an apoptotic signal molecule, ASK1, which resulted in Bcl-2 down-regulation, membrane potential disruption, decreased ATP and glucose uptake, and activation of caspases.	Hydrogen Peroxide	22-26	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	67-71	
11709494-6	2002	High concentration of H2O2 increased an apoptotic signal molecule, ASK1, which resulted in Bcl-2 down-regulation, membrane potential disruption, decreased ATP and glucose uptake, and activation of caspases.	Hydrogen Peroxide	22-26	BCL2 apoptosis regulator	Homo sapiens	91-96	
11709494-6	2002	High concentration of H2O2 increased an apoptotic signal molecule, ASK1, which resulted in Bcl-2 down-regulation, membrane potential disruption, decreased ATP and glucose uptake, and activation of caspases.	Hydrogen Peroxide	22-26	caspase 9	Homo sapiens	197-205	
11709494-6	2002	High concentration of H2O2 increased an apoptotic signal molecule, ASK1, which resulted in Bcl-2 down-regulation, membrane potential disruption, decreased ATP and glucose uptake, and activation of caspases.	Adenosine Triphosphate	155-158	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	67-71	
11709494-7	2002	However, an antiapoptotic signal molecule, Akt, was activated also by H2O2, but duration of its activation was much shorter.	Hydrogen Peroxide	70-74	AKT serine/threonine kinase 1	Homo sapiens	43-46	
11709494-8	2002	Selenite blocked apoptosis induced by H2O2, which was related to blocking ASK1 and further stimulating PI3-kinase/Akt activities.	Selenious Acid	0-8	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	74-78	
11709494-8	2002	Selenite blocked apoptosis induced by H2O2, which was related to blocking ASK1 and further stimulating PI3-kinase/Akt activities.	Selenious Acid	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	103-113	
11709494-8	2002	Selenite blocked apoptosis induced by H2O2, which was related to blocking ASK1 and further stimulating PI3-kinase/Akt activities.	Selenious Acid	0-8	AKT serine/threonine kinase 1	Homo sapiens	114-117	
11709494-8	2002	Selenite blocked apoptosis induced by H2O2, which was related to blocking ASK1 and further stimulating PI3-kinase/Akt activities.	Hydrogen Peroxide	38-42	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	74-78	
11709494-8	2002	Selenite blocked apoptosis induced by H2O2, which was related to blocking ASK1 and further stimulating PI3-kinase/Akt activities.	Hydrogen Peroxide	38-42	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	103-113	
11709494-8	2002	Selenite blocked apoptosis induced by H2O2, which was related to blocking ASK1 and further stimulating PI3-kinase/Akt activities.	Hydrogen Peroxide	38-42	AKT serine/threonine kinase 1	Homo sapiens	114-117	
11709494-10	2002	Selenite also blocked caspase-9 and -3 activities and apoptosis induced by 500 microM H2O2, even after mitochondrial membrane potential disruption.	Hydrogen Peroxide	86-90	caspase 9	Homo sapiens	22-38