Pub. Date : 2001 Nov
PMID : 11694577
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we show that lag1 Delta lac1 Delta cells have reduced sphingolipid levels due to a block of the fumonisin B1-sensitive and acyl-CoA-dependent ceramide synthase reaction. | Sphingolipids | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 2 | The sphingolipid synthesis defect in lag1 Delta lac1 Delta cells can be partially corrected by overexpression of YPC1 or YDC1, encoding ceramidases that have been reported to have acyl-CoA-independent ceramide synthesis activity. | Acyl Coenzyme A | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 3 | The sphingolipid synthesis defect in lag1 Delta lac1 Delta cells can be partially corrected by overexpression of YPC1 or YDC1, encoding ceramidases that have been reported to have acyl-CoA-independent ceramide synthesis activity. | Ceramides | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 4 | Quadruple mutant cells (lag1 Delta lac1 Delta ypc1 Delta ydc1 Delta) do not make any sphingolipids, but are still viable probably because they produce novel lipids. | Sphingolipids | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 5 | Moreover, lag1 Delta lac1 Delta cells are resistant to aureobasidin A, an inhibitor of the inositolphosphorylceramide synthase, suggesting that aureobasidin A may be toxic because it leads to increased ceramide levels. | aureobasidin A | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 6 | Moreover, lag1 Delta lac1 Delta cells are resistant to aureobasidin A, an inhibitor of the inositolphosphorylceramide synthase, suggesting that aureobasidin A may be toxic because it leads to increased ceramide levels. | aureobasidin A | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |
| 7 | Moreover, lag1 Delta lac1 Delta cells are resistant to aureobasidin A, an inhibitor of the inositolphosphorylceramide synthase, suggesting that aureobasidin A may be toxic because it leads to increased ceramide levels. | Ceramides | sphingosine N-acyltransferase LAG1 | Saccharomyces cerevisiae S288C |