Title : Molecular basis for the insulinomimetic effects of C-peptide.

Pub. Date : 2001 Oct

PMID : 11692173






4 Functional Relationships(s)
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1 We used L6 myoblasts and myocytes to measure the effects of C-peptide or insulin or both on glycogen synthesis and amino acid uptake. Glycogen insulin 2 Rattus norvegicus
2 RESULTS: In L6 cells, physiological concentrations of C-peptide (0.3-3 nmol/l) significantly activated insulin receptor tyrosine kinase, IRS-1 tyrosine phosphorylation, PI 3-kinase activity, MAPK phosphorylation, p90Rsk, and GSK3 phosphorylation. Tyrosine insulin 2 Rattus norvegicus
3 Wortmannin blocked C-peptide-induced glycogen synthesis while pertussis toxin had no effect. Wortmannin insulin 2 Rattus norvegicus
4 Wortmannin blocked C-peptide-induced glycogen synthesis while pertussis toxin had no effect. Glycogen insulin 2 Rattus norvegicus