Pub. Date : 2002 Jan 11
PMID : 11684677
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Two naturally occurring variants of TAFI (Thr-325 and Ile-325) differ substantially with respect to thermal stability and antifibrinolytic activity of the enzyme. | Threonine | carboxypeptidase B2 | Homo sapiens |
| 2 | Two naturally occurring variants of TAFI (Thr-325 and Ile-325) differ substantially with respect to thermal stability and antifibrinolytic activity of the enzyme. | Isoleucine | carboxypeptidase B2 | Homo sapiens |
| 3 | Screening of nine human cDNA libraries indicated a common variation in TAFI at position 325 (Ile-325 or Thr-325). | Isoleucine | carboxypeptidase B2 | Homo sapiens |
| 4 | Screening of nine human cDNA libraries indicated a common variation in TAFI at position 325 (Ile-325 or Thr-325). | Threonine | carboxypeptidase B2 | Homo sapiens |
| 5 | Thus, four variants of TAFI having either Ala or Thr at position 147 and either Thr or Ile at position 325 were stably expressed in baby hamster kidney cells and purified to homogeneity. | Alanine | carboxypeptidase B2 | Homo sapiens |
| 6 | Thus, four variants of TAFI having either Ala or Thr at position 147 and either Thr or Ile at position 325 were stably expressed in baby hamster kidney cells and purified to homogeneity. | Threonine | carboxypeptidase B2 | Homo sapiens |
| 7 | Thus, four variants of TAFI having either Ala or Thr at position 147 and either Thr or Ile at position 325 were stably expressed in baby hamster kidney cells and purified to homogeneity. | Threonine | carboxypeptidase B2 | Homo sapiens |
| 8 | In clot lysis assays with thrombomodulin and the TAFI variants, or with pre-activated TAFI variants, the Ile-325 variants exhibited an antifibrinolytic effect that was 60% greater than the Thr-325 variants. | Isoleucine | carboxypeptidase B2 | Homo sapiens |
| 9 | The increased antifibrinolytic potential of the Ile-325-containing TAFI variants reflects the fact that these variants have an increased ability to mediate the release of lysine from partially degraded fibrin and suppress plasminogen activation. | Isoleucine | carboxypeptidase B2 | Homo sapiens |
| 10 | The increased antifibrinolytic potential of the Ile-325-containing TAFI variants reflects the fact that these variants have an increased ability to mediate the release of lysine from partially degraded fibrin and suppress plasminogen activation. | Lysine | carboxypeptidase B2 | Homo sapiens |
| 11 | These findings imply that individuals homozygous for the Ile-325 variant of TAFI would likely have a longer lived and more potent TAFIa enzyme than those homozygous for the Thr-325 variant. | Isoleucine | carboxypeptidase B2 | Homo sapiens |
| 12 | These findings imply that individuals homozygous for the Ile-325 variant of TAFI would likely have a longer lived and more potent TAFIa enzyme than those homozygous for the Thr-325 variant. | Threonine | carboxypeptidase B2 | Homo sapiens |