Protein Name carboxypeptidase B2
Organism Homo sapiens
Gene ID 1361
Gene Symbol


UniProt Q96IY4 (CBPB2_HUMAN), A0A087WSY5 (A0A087WSY5_HUMAN)
Relationships Total Number of functionally related compound(s) : 137
Total Number of Articles : 164

carboxypeptidase B2

Gene Summary

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

  • carboxypeptidase B2
  • carboxypeptidase B-like protein
  • carboxypeptidase B2 (plasma)
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