Title : Antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappaB abrogate fulminant septic shock induced by S. typhimurium in mice.

Pub. Date : 2001 Oct

PMID : 11555406






2 Functional Relationships(s)
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1 Antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappaB abrogate fulminant septic shock induced by S. typhimurium in mice. Phosphorothioate Oligonucleotides v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus
2 Treatment with specific antisense oligonucleotides against the p65 subunit of NF-kappaB 24 h before infection prevented the development of fulminant, lethal septic shock and was associated with a significant increase of survival. Oligonucleotides v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus