Pub. Date : 2001 Nov 16
PMID : 11553641
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Several lines of evidence have indicated that tamoxifen promotes association between ERalpha and corepressors N-CoR or silencing mediator for retinoid and thyroid hormone receptor (SMRT). | Tamoxifen | nuclear receptor corepressor 1 | Homo sapiens |
| 2 | Our results indicate that N-CoR/SMRT recognize and interact with helices H3 and H5 of the ERalpha ligand-binding domain in a 4-hydroxy tamoxifen-dependent manner. | Tamoxifen | nuclear receptor corepressor 1 | Homo sapiens |
| 3 | The mutant ERalpha(D351Y), derived from a tamoxifen-stimulated tumor and containing an amino acid substitution at position 351 within H3, showed reduced interaction with N-CoR/SMRT and high tamoxifen-induced activation function-1 (AF-1) activity. | Tamoxifen | nuclear receptor corepressor 1 | Homo sapiens |