| Protein Name | nuclear receptor corepressor 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 9611 |
| Gene Symbol | NCOR1 |
| UniProt | O75376 (NCOR1_HUMAN), A0A024RD47 (A0A024RD47_HUMAN), Q6PGR4 (Q6PGR4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
98
Total Number of Articles : 149 |
Description |
nuclear receptor corepressor 1 |
| Gene Summary |
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010] |
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| Properties | |