Pub. Date : 2001 Sep
PMID : 11502895
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A phenylalanine residue at segment D3-S6 in Nav1.4 voltage-gated Na(+) channels is critical for pyrethroid action. | Phenylalanine | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |
| 2 | A background mutation, Nav1.4-I687M (within D2:S4-S5 cytoplasmic linker), enhanced the deltamethrin-induced maintained current by approximately 2.5-fold, whereas Nav1.4-I687T, a homologous superkdr mutation, reduced it by approximately 2-fold. | decamethrin | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |
| 3 | Repetitive pulses at 2 Hz further augmented the effects of deltamethrin on Nav1.4-I687M mutant channels so that approximately 75% of peak currents were maintained. | decamethrin | sodium voltage-gated channel alpha subunit 4 | Homo sapiens |