Pub. Date : 2001 Sep
PMID : 11502873
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ADP-induced platelet aggregation is mediated by two distinct G protein-coupled ADP receptors, Gq-linked P2Y(1), and Gi-linked P2T(AC), which has not been cloned. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
| 2 | HORK3, when transfected in the rat glioma cell subline (C6-15), responded to 2-methylthio-ADP (2MeSADP) (EC(50) = 0.08 nM) and ADP (EC(50) = 42 nM) with inhibition of forskolin-stimulated cAMP accumulation. | methylthio-ADP | purinergic receptor P2Y12 | Homo sapiens |
| 3 | HORK3, when transfected in the rat glioma cell subline (C6-15), responded to 2-methylthio-ADP (2MeSADP) (EC(50) = 0.08 nM) and ADP (EC(50) = 42 nM) with inhibition of forskolin-stimulated cAMP accumulation. | methylthio-ADP | purinergic receptor P2Y12 | Homo sapiens |
| 4 | HORK3, when transfected in the rat glioma cell subline (C6-15), responded to 2-methylthio-ADP (2MeSADP) (EC(50) = 0.08 nM) and ADP (EC(50) = 42 nM) with inhibition of forskolin-stimulated cAMP accumulation. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
| 5 | HORK3, when transfected in the rat glioma cell subline (C6-15), responded to 2-methylthio-ADP (2MeSADP) (EC(50) = 0.08 nM) and ADP (EC(50) = 42 nM) with inhibition of forskolin-stimulated cAMP accumulation. | Colforsin | purinergic receptor P2Y12 | Homo sapiens |
| 6 | HORK3, when transfected in the rat glioma cell subline (C6-15), responded to 2-methylthio-ADP (2MeSADP) (EC(50) = 0.08 nM) and ADP (EC(50) = 42 nM) with inhibition of forskolin-stimulated cAMP accumulation. | Cyclic AMP | purinergic receptor P2Y12 | Homo sapiens |
| 7 | These results show that HORK3 is a Gi/o-coupled receptor and that its natural ligand is ADP. | Adenosine Diphosphate | purinergic receptor P2Y12 | Homo sapiens |
| 8 | We have also determined that [(3)H]2MeSADP binds to cloned HORK3 and P2Y(1). | methylthio-ADP | purinergic receptor P2Y12 | Homo sapiens |