Pub. Date : 2001 May 31
PMID : 11385574
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we describe the cloning and functional characterization of a Ca2+- and Mg2+-permeable divalent cation channel, LTRPC7 (nomenclature compatible with that proposed in ref. | magnesium ion | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 2 | Electrophysiological analysis of HEK-293 cells overexpressing recombinant LTRPC7 showed large currents regulated by millimolar levels of intracellular Mg.ATP and Mg.GTP with the permeation properties of a voltage-independent divalent cation influx pathway. | Magnesium | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 3 | Electrophysiological analysis of HEK-293 cells overexpressing recombinant LTRPC7 showed large currents regulated by millimolar levels of intracellular Mg.ATP and Mg.GTP with the permeation properties of a voltage-independent divalent cation influx pathway. | Adenosine Triphosphate | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 4 | Electrophysiological analysis of HEK-293 cells overexpressing recombinant LTRPC7 showed large currents regulated by millimolar levels of intracellular Mg.ATP and Mg.GTP with the permeation properties of a voltage-independent divalent cation influx pathway. | Magnesium | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 5 | Electrophysiological analysis of HEK-293 cells overexpressing recombinant LTRPC7 showed large currents regulated by millimolar levels of intracellular Mg.ATP and Mg.GTP with the permeation properties of a voltage-independent divalent cation influx pathway. | Guanosine Triphosphate | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 6 | Analysis of several cultured cell types demonstrated small magnesium-nucleotide-regulated metal ion currents (MagNuM) with regulation and permeation properties essentially identical to the large currents observed in cells expressing recombinant LTRPC7. | magnesium-nucleotide | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 7 | Analysis of several cultured cell types demonstrated small magnesium-nucleotide-regulated metal ion currents (MagNuM) with regulation and permeation properties essentially identical to the large currents observed in cells expressing recombinant LTRPC7. | Metals | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |
| 8 | Our data indicate that LTRPC7, by virtue of its sensitivity to physiological Mg.ATP levels, may be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. | Adenosine Triphosphate | transient receptor potential cation channel subfamily M member 7 | Homo sapiens |