Title : Intracellular aromatase and its relevance to the pharmacological efficacy of aromatase inhibitors.

Pub. Date : 2001 Jan-Mar

PMID : 11384878






1 Functional Relationships(s)
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1 Although letrozole and anastrozole are approximately equipotent in a cell-free aromatase system (human placental microsomes), letrozole is consistently 10-30 times more potent than anastrozole in inhibiting intracellular aromatase in intact rodent cells, normal human adipose fibroblasts and human cancer cell lines. Anastrozole cytochrome P450 family 19 subfamily A member 1 Homo sapiens