Pub. Date : 2001 Jun
PMID : 11375961
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although glycochenodeoxycholate (GCDC) induces Fas-mediated hepatocyte apoptosis, taurochenodeoxycholate (TCDC) simultaneously activates a phosphatidylinositol 3-kinase (PI 3-K)-mediated survival pathway blocking Fas apoptosis. | Taurochenodeoxycholic Acid | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | Rattus norvegicus |
| 2 | Although glycochenodeoxycholate (GCDC) induces Fas-mediated hepatocyte apoptosis, taurochenodeoxycholate (TCDC) simultaneously activates a phosphatidylinositol 3-kinase (PI 3-K)-mediated survival pathway blocking Fas apoptosis. | Taurochenodeoxycholic Acid | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma | Rattus norvegicus |
| 3 | However, when PI-3K was inhibited with wortmannin or dominant-negative PI 3-K, TCDC-induced Bid-GFP mitochondrial translocation and cytochrome c release. | Taurochenodeoxycholic Acid | BH3 interacting domain death agonist | Rattus norvegicus |
| 4 | CONCLUSIONS: The TCDC/PI 3-K survival signal blocks Fas-mediated apoptosis by preventing caspase 8 activation and Bid mitochondrial translocation. | Taurochenodeoxycholic Acid | caspase 8 | Rattus norvegicus |
| 5 | CONCLUSIONS: The TCDC/PI 3-K survival signal blocks Fas-mediated apoptosis by preventing caspase 8 activation and Bid mitochondrial translocation. | Taurochenodeoxycholic Acid | BH3 interacting domain death agonist | Rattus norvegicus |