Protein Name caspase 8
Organism Rattus norvegicus
Gene ID 64044
Gene Symbol

Casp8

UniProt Q9JHX4 (CASP8_RAT)
Relationships Total Number of functionally related compound(s) : 314
Total Number of Articles : 367
Description

caspase 8

Gene Summary

Enables cysteine-type endopeptidase activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including response to estradiol; response to ethanol; and response to lipopolysaccharide. Located in several cellular components, including cell body; cytosol; and membrane raft. Part of CD95 death-inducing signaling complex. Used to study pre-malignant neoplasm. Biomarker of several diseases, including heart disease (multiple); kidney disease (multiple); retinal detachment; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and primary immunodeficiency disease. Orthologous to human CASP8 (caspase 8). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • caspase-8
  • CASP-8
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Properties